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Latest Depression Treatments The good news is that if your depression does not improve after psychotherapy and antidepressants, new fast-acting drugs offer promise in treating depression resistant to treatment. SSRIs are the most well-known and well-known antidepressants. They alter how the brain processes serotonin as the chemical messenger. Cognitive behavioral therapy (CBT), also known as cognitive behavioral therapy, assists you in changing negative thoughts and behaviors, such as despair. The NHS offers 8 to 16 sessions. 1. Esketamine The FDA approved a new treatment for depression in March 2019 nasal spray known as esketamine (brand name Spravato). It is made from the anesthetic ketamine, which has been shown to help in severe cases of depression. The nasal spray is utilized in conjunction with an oral antidepressant for depression that hasn't responded to standard medication. In one study, 70% of people with treatment resistant depression who were given this drug were able to respond well, which is a significantly higher response rate than just using an oral antidepressant. Esketamine acts differently than conventional antidepressants. It increases the amount of neurotransmitters in the brain that transmit messages between brain cells. The effects aren't immediately apparent. Patients generally feel better within a few days, but effects last longer than SSRIs and SNRIs. Researchers believe that esketamine reduces symptoms of depression through strengthening connections between brain cells. In animal studies, esketamine reversed these connections which are weakened through depression and chronic stress. In addition, it seems to promote the growth of neurons that can help to reduce suicidal ideas and feelings. Esketamine differs from other antidepressants because it is delivered via nasal spray. This allows it to get into your bloodstream much faster than pill or oral medication. The drug has been shown by studies to decrease depression symptoms within a couple of hours. In certain instances the effects may be almost immediate. However the results of a study that tracked patients for 16 weeks revealed that not all who began treatment with esketamine continued to be in Remission. This is disappointing but not unexpected, according Dr. holistic depression treatment , an expert on ketamine but not part of the study. Esketamine is currently only available in private practice or in clinical trials. Esketamine is not a first-line treatment for depression. It is prescribed when SSRIs and SNRIs don't be effective for a patient suffering from treatment-resistant depressive disorder. Doctors can determine if the condition is resistant to treatment, and then determine whether esketamine could be beneficial. 2. TMS TMS makes use of magnetic fields to stimulate neurons in the brain. It is non-invasive and does not require surgery or anesthesia. It has been proven to help patients suffering from depression who have not been able to respond to medication or psychotherapy. It's also been used to treat the disorder of obsessive compulsiveness and tinnitus (ringing in the ear). For depression, TMS therapy is typically given in a series of 36 daily treatments over six weeks. The magnetic pulses can feel like pinpricks on the scalp. It could take some time to become accustomed to. After the treatment, patients are able to return to work or at home. Depending on the stimulation pattern used and the stimulation pattern used, each TMS session can last between 3.5 and 20 minutes. Researchers believe that rTMS alters the way that neurons communicate. This process, referred to as neuroplasticity, allows the brain to create new connections and alter its functions. At present, TMS is FDA-cleared to help with depression when other treatments like talk therapy or medications, haven't succeeded. It has also been shown to help people with tinnitus, OCD and pain. Scientists are currently examining whether it can be used to treat Parkinson's disease. TMS has been shown to help with depression in a number studies, but not everyone who receives it benefits. Before attempting this type of treatment, it is essential to undergo a thorough medical and psychiatric evaluation. If you have any history of seizures or are taking certain medications, TMS might not be right for you. If you've been struggling with depression and aren't seeing the benefits of your current treatment plan, having a discussion with your psychiatrist could be beneficial. You could be a good candidate to try TMS or other forms of neurostimulation, but you need to try various antidepressants before insurance coverage can cover the cost. If you are interested in knowing more about these life-changing treatments, call us today for a consultation. Our specialists can assist you in the process of deciding whether TMS is the best choice for you. 3. Deep brain stimulation A noninvasive therapy that resets the brain's circuitry may be effective in just one week for those suffering from treatment resistant depression. Researchers have developed new methods that deliver high-dose magnetic signals to the brain faster and at a time that is more manageable for patients. Stanford neuromodulation therapy, now available in the Advanced Psychiatric Therapeutics Clinic at the UC Davis Department of Psychiatry and Behavioral Sciences It uses MRI images to direct electrodes to send magnetic pulses into specific areas of the brain. In a recent study, Mitra & Raichle found that in three quarters (or more) of patients with depression, the normal flow of neural activity was disrupted, shifting from the anterior cortex to the anterior cortex. With SNT this flow was restored to normal within a week, coinciding with a lifting of their depression. A more in-depth procedure known as deep brain stimulation (DBS) can yield similar results for some patients. Neurosurgeons conduct a series of tests to determine the ideal placement before implanting one or more leads into the brain. The leads are connected to a neurostimulator implanted under the collarbone. It appears like a heart pacemaker. The device delivers continuous electrical current to the leads, which alters the brain's natural circuitry and helps reduce depression symptoms. Certain psychotherapy treatments can help relieve depression symptoms, including cognitive behavior therapy and interpersonal therapy. Psychotherapy can take place in an environment of group or one-on-one sessions with a mental healthcare professional. Some therapists also offer telehealth services. Antidepressants are the mainstay of treatment for depression. In recent times, however, there have also been notable improvements in how quickly they can alleviate depressive symptoms. Newer drugs, such as gepirone (Exxua), esketamine (Spravato), brexanolone (Zulresso) and dextromethorphan-bupropion (Auvelity), all have been shown to work faster than older antidepressants. Other therapies use electric or magnetic stimulation to stimulate the brain, like electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS). These are more complex procedures that require the supervision of a physician. In certain instances they can trigger seizures or other serious side effects. 4. Light therapy Bright light therapy, which involves working or sitting in front of a bright artificial light source, has been used for many years to treat major depressive disorder with seasonal patterns (SAD). Studies show that bright light therapy can help reduce symptoms like fatigue and sadness by improving mood and regulating circadian rhythms. It is also beneficial for those suffering from depression that is intermittent. Light therapy mimics the sun, which is a major element of a biological clock referred to as suprachiasmatic (SCN). The SCN is linked to mood, and light therapy can rewire misaligned circadian rhythm patterns that may contribute to depression. Light therapy can also decrease Melatonin levels and help restore the function of neurotransmitters. Some doctors utilize light therapy to treat winter blues. This is a milder version of depression that is similar to SAD but has fewer people affected and is most prevalent in the seasons when there is the least amount of daylight. They suggest sitting in the light therapy device each morning for 30 minutes while awake to reap the most benefits. Light therapy results are seen in one week, unlike antidepressants which can take a long time to kick in and may trigger adverse effects like nausea or weight gain. It's also safe to use during pregnancy and in older adults. Researchers advise against using light therapy without the supervision of a mental health professional or psychiatrist, as it could trigger manic episodes for people with bipolar disorders. It may also make some people feel tired in the first week of treatment as it can alter their sleep and wake patterns. PCPs must be aware of new treatments that have been approved by the FDA, but they shouldn't neglect tried-and-true methods like antidepressants and cognitive behavioral therapy. “The quest for newer and better treatments is exciting, but we should continue to prioritize the best-established therapies,” Dr. Hellerstein informs Healio. He says that PCPs should concentrate on educating their patients on the benefits of new options and helping them adhere to their treatment strategies. This can include providing transportation to the doctor's office, or setting up reminders to patients to take their medication and attend therapy sessions.